- Upfront pricingOur total price for your stay includes taxes and fees
- Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member Prices
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Downtown Clayton hotels

1. Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
2. AC Hotel St. Louis Clayton
AC Hotel St. Louis Clayton
3. Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton
4. Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
5. The Ritz-Carlton, St. Louis
The Ritz-Carlton, St. Louis
6. Drury Plaza Hotel St. Louis Brentwood
Drury Plaza Hotel St. Louis Brentwood
7. Courtyard by Marriott St. Louis Brentwood
Courtyard by Marriott St. Louis Brentwood
8. The Knight Center at Washington University
The Knight Center at Washington University
9. Moonrise Hotel
Moonrise Hotel
10. The Cheshire
The Cheshire
11. Hampton Inn & Suites St. Louis at Forest Park
Hampton Inn & Suites St. Louis at Forest Park
12. The Royal Sonesta Chase Park Plaza St. Louis
The Royal Sonesta Chase Park Plaza St. Louis
13. Forest Park Hotel by MDR
Forest Park Hotel by MDR
14. The West End
The West End
15. Hilton Garden Inn St. Louis Airport
Hilton Garden Inn St. Louis Airport
16. Drury Inn & Suites St. Louis Forest Park
Drury Inn & Suites St. Louis Forest Park
17. Pear Tree Inn St. Louis Airport
Pear Tree Inn St. Louis Airport
18. Hyatt Select St. Louis Airport
Hyatt Select St. Louis Airport
19. La Quinta Inn & Suites by Wyndham St Louis Route 66
La Quinta Inn & Suites by Wyndham St Louis Route 66
20. Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. LouisCompare popular hotels in Downtown Clayton
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() AC Hotel St. Louis Clayton | 9.2 Wonderful 426 reviews | View | ||||||
![]() The Ritz-Carlton, St. Louis | 9.2 Wonderful 588 reviews | View | ||||||
![]() Clayton Plaza Hotel & Extended Stay | 8.8 Excellent 3,530 reviews | View | ||||||
![]() Le Méridien St. Louis Clayton | 8.8 Excellent 802 reviews | View | ||||||
![]() Seven Gables, St. Louis West, a Tribute Portfolio Hotel | 8.4 Very good 603 reviews | View |
Where to stay in Downtown Clayton

Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

St. Charles Historic District
Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.
Top Downtown Clayton Hotel Reviews



















































































































